Published in
MDPI, International Journal of Molecular Sciences, 2(24), p. 1703, 2023
DOI: 10.3390/ijms24021703
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GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives
,
Raffaella Epifani,
Simona Imbriani,
Giovanni Tortorella ,
Concetta Aprea,
Raffaele Galiero ,
Luca Rinaldi ,
Raffaele Marfella ,
Ferdinando Carlo Sasso
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Abstract
To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease, affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available for its treatment. Beyond their anti-hyperglycemic effect and the surprising role of cardio- and nephroprotection, GLP-1 receptor agonists (GLP-1 RAs) have shown a significant impact on body weight and clinical, biochemical and histological markers of fatty liver and fibrosis in patients with NAFLD. Therefore, GLP-1 RAs could be a weapon for the treatment of both diabetes mellitus and NAFLD. The aim of this review is to summarize the evidence currently available on the role of GLP-1 RAs in the treatment of NAFLD and to hypothesize potential future scenarios.