Facebook is one the most popular social networking sites in the world. The social aspect and perceiving oneself in the context of relationships seem to be crucial in the analysis of Facebook use. In recent years the number of Facebook users has been increasing, which is related to the problem of Facebook intrusion. Machiavellianism and selected interdependence agency indicators (conformity, relatedness, and autonomy) are associated with social functioning, which is an important aspect of Facebook intrusion. The aim of the study was to check how Machiavelianism and the interdependent agency indicators mentioned above affect Facebook intrusion and whether Facebook intrusion decreases satisfaction with life. The participants in the online study were 715 Polish Facebook users. We administered the Facebook Intrusion Scale, Conformity, Relatedness, and Autonomy Scales, and the Satisfaction With Life Scale. The results show that the selected interdependence agency indicators predict Facebook intrusion. Our results revealed that a high level of Machiavellianism was related to a high level of Facebook intrusion in women. They also show that conformity is positively and autonomy negatively related to Facebook intrusion and that Facebook decreases reduces satisfaction with life. The presented research thus contributes to knowledge about Facebook usage patterns.