An airborne microwave wide-band radiometer (500–2000 MHz) was operated for the first time in Antarctica to better understand the emission properties of sea ice, outlet glaciers and the interior ice sheet from Terra Nova Bay to Dome C. The different glaciological regimes were revealed to exhibit unique spectral signatures in this portion of the microwave spectrum. Generally, the brightness temperatures over a vertically homogeneous ice sheet are warmest at the lowest frequencies, consistent with models that predict that those channels sensed the deeper, warmer parts of the ice sheet. Vertical heterogeneities in the ice property profiles can alter this basic interpretation of the signal. Spectra along the lengths of outlet glaciers were modulated by the deposition and erosion of snow, driven by strong katabatic winds. Similar to previous experiments in Greenland, the brightness temperatures across the frequency band were low in crevasse areas. Variations in brightness temperature were consistent with spatial changes in sea ice type identified in satellite imagery and in situ ground-penetrating radar data. The results contribute to a better understanding of the utility of microwave wide-band radiometry for cryospheric studies and also advance knowledge of the important physics underlying existing L-band radiometers operating in space.