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Hindawi, BioMed Research International, (2015), p. 1-10

DOI: 10.1155/2015/461593

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Robust Association Tests for the Replication of Genome-Wide Association Studies

Journal article published in 2015 by Jungnam Joo ORCID, Ju-Hyun Park, Bora Lee, Boram Park ORCID, Sohee Kim ORCID, Kyong-Ah Yoon, Jin Soo Lee, Nancy L. Geller
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In genome-wide association study (GWAS), robust genetic association tests such as maximum of three CATTs (MAX3), each corresponding to recessive, additive, and dominant genetic models, the minimum p value of Pearson’s Chi-square test with 2 degrees of freedom, and CATT based on additive genetic model (MIN2), genetic model selection (GMS), and genetic model exclusion (GME) methods have been shown to provide better power performance under wide range of underlying genetic models. In this paper, we demonstrate how these robust tests can be applied to the replication study of GWAS and how the overall statistical significance can be evaluated using the combined test formed by p values of the discovery and replication studies.