Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression
Journal article published in 2023 by
Emi Hashizaki,
Miwa Sasai 
,
Daisuke Okuzaki ,
Tsubasa Nishi,
Takashi Kobayashi,
Shiroh Iwanaga,
Masahiro Yamamoto
,
Daisuke Okuzaki ,
Tsubasa Nishi,
Takashi Kobayashi,
Shiroh Iwanaga,
Masahiro Yamamoto
This paper is made freely available by the publisher.
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Abstract
The parasite Toxoplasma gondii has a counterdefense system against interferon-γ (IFN-γ)-dependent host immunity which relies on the secretion of parasite effector proteins. ROP18 is one of the effector, which is released into host cells to inactivate IFN-γ-dependent anti- Toxoplasma host proteins. The mechanism by which Toxoplasma ROP18 subverts host immunity has been extensively analyzed, but how Toxoplasma produces this virulence factor remains unclear.