Published in
Wiley, HIV Medicine, 3(4), p. 255-262, 2003
DOI: 10.1046/j.1468-1293.2003.00156.x
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Factors associated with a reduced CD4 lymphocyte count response to HAART despite full viral suppression in the EuroSIDA study
,
J. van Lunzen,
J. Lundgren,
H.-J. Stellbrink,
C. Dreezen,
S. Staszewski,
F.-D. Goebel,
I. Yust,
B. Salzberger,
J. Rockstroh,
M. Fisher,
J. Kosmidis,
P. Gargalianos,
H. Sambatakou,
J. Perdios
and other authors.
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Abstract
The definitive version is available at www3.interscience.wiley.com ; OBJECTIVES: To describe the prevalence and risk factors of poor CD4 count rise despite a good virological response on highly active antiretroviral treatment (HAART). METHODS: The patients from the EuroSIDA study who started HAART with a baseline CD4 count of or =one drug from each of the three antiviral classes were more likely to have a good CD4 response but a minority of the study participants was taking this treatment regimen (3.1%) and the confidence interval was large. CONCLUSIONS: A poor immune reconstitution despite a good virological control is frequent after initiation of HAART among patients with a baseline CD4 count of