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American Physiological Society, AJP - Endocrinology and Metabolism, 2(326), p. E166-E177, 2024

DOI: 10.1152/ajpendo.00281.2023

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Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration

Journal article published in 2024 by Giovanna Notaristefano ORCID, Francesca Romana Ponziani, Monia Ranalli, Alice Diterlizzi, Martina Asia Policriti, Leonardo Stella, Fabio Del Zompo ORCID, Francesca Fianchi, Anna Picca ORCID, Valentina Petito, Federica Del Chierico, Matteo Scanu, Francesca Toto, Lorenza Putignani, Emanuele Marzetti ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Our study marks the first comprehensive analysis of gut microbiota composition in FHA and the impact of HRT on it, along with biochemical, anthropometric, and psychometric aspects. Our results indicate distinct gut microbiota composition in patients with FHA compared with healthy individuals. Importantly, HRT prompts a transition toward a more beneficial gut microbiota profile and reduced inflammation. This study validates the concept of FHA as a multifaceted disorder interlinked with dysbiosis, particularly involving the gut-brain axis.