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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2023

DOI: 10.1128/aac.01493-22

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Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs

Journal article published in 2023 by Irene Hernández-Lozano, Severin Mairinger ORCID, Thomas Filip, Mathilde Löbsch, Johann Stanek, Claudia Kuntner, Martin Bauer, Markus Zeitlinger ORCID, Marcus Hacker, Thomas H. Helbich, Thomas Wanek, Oliver Langer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Transporter-mediated drug-drug interactions (DDIs) are of concern in antimicrobial drug development, as they can have serious safety consequences. We used positron emission tomography (PET) imaging-based pharmacokinetic (PK) analysis to assess the effect of different drugs, which may cause transporter-mediated DDIs, on the tissue distribution and excretion of [ 18 F]ciprofloxacin as a radiolabeled model antimicrobial drug.