Plasma-facing materials (PFMs) in the ITER divertor will be exposed to severe conditions, including exposure to transient heat loads from edge-localized modes (ELMs) and to plasma particles and neutrons. Tungsten is the material chosen as PFM for the ITER divertor. In previous tests, bubble formation in ITER-grade tungsten was detected when exposed to fusion relevant conditions. For this study, ITER-grade tungsten was exposed to simultaneous ELM-like transient heat loads and D/He (6%) plasma in the linear plasma device PSI-2. Bubble formation was then investigated via SEM micrographs and FIB cuts. It was found that for exposure to 100.000 laser pulses of 0.6 GWm−2 absorbed power density (Pabs), only small bubbles in the nanometer range were formed close to the surface. After increasing Pabs to 0.8 and 1.0 GWm−2, the size of the bubbles went up to about 1 µm in size and were deeper below the surface. Increasing the plasma fluence had an even larger effect, more than doubling bubble density and increasing bubble size to up to 2 µm in diameter. When using deuterium-only plasma, the samples showed no bubble formation and reduced cracking, showing such bubble formation is caused by exposure to helium plasma.