Published in
American Society for Microbiology, Microbiology Spectrum, 2023
DOI: 10.1128/spectrum.05079-22
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Pharmacokinetics of Bictegravir in Older Japanese People Living with HIV-1
Journal article published in 2023 by
Akira Kawashima 
,
Hieu Tran Trung,
Koji Watanabe ,
Misao Takano,
Yoshimi Deguchi,
Mai Kinoshita,
Haruka Uemura,
Yasuaki Yanagawa,
Hiroyuki Gatanaga,
Yoshimi Kikuchi,
Shinichi Oka,
Kiyoto Tsuchiya
,
Hieu Tran Trung,
Koji Watanabe ,
Misao Takano,
Yoshimi Deguchi,
Mai Kinoshita,
Haruka Uemura,
Yasuaki Yanagawa,
Hiroyuki Gatanaga,
Yoshimi Kikuchi,
Shinichi Oka,
Kiyoto Tsuchiya
This paper is made freely available by the publisher.
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Abstract
BIC is a potent integrase strand transfer inhibitor (INSTI), widely used for the treatment of HIV-1 as part of a once-daily single-tablet regimen that includes emtricitabine and tenofovir alafenamide (BIC+FTC+TAF). Although the safety and efficacy of BIC+FTC+TAF have been confirmed in older patients with HIV-1, PK data in this patient population remain limited.