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Nature Research, Nature Genetics, 3(43), p. 185-187

DOI: 10.1038/ng.760

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Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.

Journal article published in 2011 by Sara Lindström, Cm Vachon, Jingmei Li, Jajini Varghese, Deborah Thompson, Ruth Warren, Judith Brown, Jean Leyland, Tina Audley, Nj Wareham, Rj Loos, Ad Paterson, Johanna Rommens, Darryl Waggott, Lj Martin and other authors.
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This paper is available in a repository.

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Abstract

High percent mammographic density adjusted for age and body mass index (BMI) is one of the strongest risk factors for breast cancer. We conducted a meta-analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P=9×6·10−10). This finding might partly explain the underlying biology of the recently discovered association between common variants in ZNF365 and breast cancer risk.