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Wiley, FEBS Letters, 2-3(474), p. 146-150, 2000

DOI: 10.1016/s0014-5793(00)01566-0

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Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

Journal article published in 2000 by Anette Sommer ORCID, H. Burkhardt, Steven M. Keyse, Bernhard Lüscher
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.