Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2023
DOI: 10.1128/aac.01687-22
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Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection
Journal article published in 2023 by
Nereida Jiménez de Oya 
,
Ana San-Félix,
Mireia Casasampere,
Ana-Belén Blázquez ,
Patricia Mingo-Casas,
Estela Escribano-Romero ,
Eva Calvo-Pinilla ,
Teresa Poderoso,
Josefina Casas,
Juan-Carlos Saiz,
María-Jesús Pérez-Pérez,
Miguel A. Martín-Acebes
,
Ana San-Félix,
Mireia Casasampere,
Ana-Belén Blázquez ,
Patricia Mingo-Casas,
Estela Escribano-Romero ,
Eva Calvo-Pinilla ,
Teresa Poderoso,
Josefina Casas,
Juan-Carlos Saiz,
María-Jesús Pérez-Pérez,
Miguel A. Martín-Acebes
This paper is made freely available by the publisher.
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Abstract
The flavivirus life cycle is strictly dependent on cellular lipid metabolism. Polyphenols like gallic acid and its derivatives are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of lipid metabolism.