In a national sample of 5087 Spaniards, we examine the prevalence of 10 specific misperceptions over five separate science and health domains (climate change, 5G technology, genetically modified foods, vaccines, and homeopathy). We find that misperceptions about genetically modified foods and general health risks of 5G technology are particularly widespread. While we find that partisan affiliation is not strongly associated with any of the misperceptions aside from climate change, we find that two distinct dimensions of an anti-elite worldview—anti-expert and conspiratorial mindsets—are better overall predictors of having science and health misperceptions in the Spanish context. These findings help extend our understanding of polarization around science beyond the most common contexts (e.g. the United States) and support recent work suggesting anti-elite sentiments are among the most important predictors of factual misperceptions.