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Public Library of Science, PLoS ONE, 5(9), p. e97030, 2014

DOI: 10.1371/journal.pone.0097030

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Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses

Journal article published in 2014 by Jérome T. Jérôme Nicol, Etienne Liais, Romain Potier, Elisa Mazzoni, Mauro Tognon, Pierre Coursaget, Antoine Touze
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera. ; Peer reviewed