Published in
American Society for Microbiology, Journal of Bacteriology, 2023
DOI: 10.1128/jb.00456-22
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Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin
Journal article published in 2023 by
Jory A. Goldsmith,
Vincent Dewar,
Philippe Hermand,
Normand Blais 
,
Jason S. McLellan
,
Jason S. McLellan
This paper is made freely available by the publisher.
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Abstract
Clostridioides difficile strains associated with worse clinical outcomes have been found to secrete a toxin called CDT (or binary toxin). As blocking the function of this toxin could help mitigate C. difficile infections, we sought to determine the molecular basis for the inhibition of CDT by monoclonal antibodies.