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American Society for Microbiology, Journal of Virology, 2023

DOI: 10.1128/jvi.01864-22

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Effect of Passive Administration of Monoclonal Antibodies Recognizing Simian Immunodeficiency Virus (SIV) V2 in CH59-Like Coil/Helical or β-Sheet Conformations on Time of SIV <sub>mac251</sub> Acquisition

Journal article published in 2023 by James D. Stamos ORCID, Mohammad Arif Rahman ORCID, Giacomo Gorini, Isabela Silva de Castro ORCID, Manuel Becerra-Flores, David J. Van Wazer ORCID, Kombo F. N’Guessan, Natasha M. Clark, Massimiliano Bissa ORCID, Anna Gutowska ORCID, Rosemarie D. Mason, Jiae Kim, Mangala Rao, Mario Roederer, Dominic Paquin-Proulx and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Studies suggest that the protection against SIV/simian-human immunodeficiency virus (SHIV) acquisition afforded by the SIV/HIV V1 deletion-containing envelope immunogens, delivered by the DNA/ALVAC vaccine platform, requires multiple innate and adaptive host responses. Anti-inflammatory macrophages and tolerogenic dendritic cells (DC-10), together with CD14 + efferocytes, are consistently found to correlate with a vaccine-induced decrease in the risk of SIV/SHIV acquisition.