Links

Tools

Export citation

Search in Google Scholar

Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis

Journal article published in 2012 by James Venturini, Alvares Am, Anuska Marcelino Alvares, Anuska Marcelino Álvares, Marcela Rodrigues D. de Camargo, Marcela Rodrigues de Camargo, Camargo Mr, Marchetti Cm, Camila Martins Marchetti, M. S. P. de Arruda, Thais Fernanda de Campos Fraga-Silva, Thais Fernanda de Campos Fraga-Silva ORCID, Fraga Silva Tf, Ana Carolina Luchini, Luchini Ac and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Recognizing the invasive potential of the dermatophytes and understanding the mechanisms involved in this process will help with disease diagnosis and with developing an appropriate treatment plan. In this report, we present the histopathological, microbiological and immunological features of a model of invasive dermatophytosis that is induced by subcutaneous infection of Trichophyton mentagrophytes in healthy adult Swiss mice. Using this model, we observed that the fungus rapidly spreads to the popliteal lymph nodes, spleen, liver and kidneys. Similar to the human disease, the lymph nodes were the most severely affected sites. The fungal infection evoked acute inflammation followed by a granulomatous reaction in the mice, which is similar to what is observed in patients. The mice were able to mount a Th1-polarized immune response and displayed IL-10-mediated immune regulation. We believe that the model described here will provide valuable information regarding the dermatophyte-host relationship and will yield new perspective for a better understanding of the immunological and pathological aspects of invasive dermatophytosis. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.