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European Centre for Disease Prevention and Control, Eurosurveillance, 31(27), 2022

DOI: 10.2807/1560-7917.es.2022.27.31.2200561

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Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022

Journal article published in 2022 by Rebecca Amati, Anja Frei, Marco Kaufmann, Céline Pellaton, Jan Fehr, Serena Sabatini ORCID, Emiliano Albanese, Milo A. Puhan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8–98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.