A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model
Journal article published in 2021 by
Shirin Strohmeier,
Fatima Amanat,
Xueyong Zhu,
Meagan McMahon 
,
Meagan E. Deming,
Marcela F. Pasetti,
Kathleen M. Neuzil,
Ian A. Wilson,
Florian Krammer
,
Meagan E. Deming,
Marcela F. Pasetti,
Kathleen M. Neuzil,
Ian A. Wilson,
Florian Krammer
This paper is made freely available by the publisher.
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Abstract
Influenza virus infections remain a high risk to human health, causing up to 650,000 deaths worldwide every year, with an enormous burden on the health care system. Since currently available seasonal vaccines are only partially effective and often mismatched to the circulating strains, a broader protective influenza virus vaccine is needed.