Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model
Journal article published in 2022 by
Jessica Tan 
,
Veronika Chromikova,
George O'Dell,
Emilia Mia Sordillo,
Viviana Simon,
Harm van Bakel,
Florian Krammer ,
Meagan McMahon
,
Veronika Chromikova,
George O'Dell,
Emilia Mia Sordillo,
Viviana Simon,
Harm van Bakel,
Florian Krammer ,
Meagan McMahon
This paper is made freely available by the publisher.
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Abstract
The global health burden of influenza B viruses, especially in children, has long been underappreciated. Although two antigenically distinct influenza B virus lineages cocirculated before the coronavirus disease 2019 (COVID-19) pandemic, the commonly used trivalent seasonal vaccines contain antigens from only one influenza B virus, providing limited cross-protection against viruses of the other lineage.