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American Society for Microbiology, Journal of Virology, 6(87), p. 3592-3596, 2013

DOI: 10.1128/jvi.02657-12

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Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Journal article published in 2013 by Wiebke Handke, Christina Luig, Branka Popović, Astrid Krmpotić, Stipan Jonjić, Wolfram Brune ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1 −/− mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo .