Abstract Stellar variability is a key obstacle in reaching the sensitivity required to recover Earth-like exoplanetary signals using the radial velocity (RV) detection method. To explore activity signatures in Sun-like stars, we present SolAster, a publicly distributed analysis pipeline ^{10 10} https://tamarervin.github.io/SolAster/ that allows for comparison of space-based measurements with ground-based disk-integrated RVs. Using high-spatial-resolution Dopplergrams, magnetograms, and continuum filtergrams from the Helioseismic and Magnetic Imager aboard the Solar Dynamics Observatory (SDO), we estimate “Sun-as-a-star” disk-integrated RVs due to rotationally modulated flux imbalances and convective blueshift suppression, as well as other observables such as unsigned magnetic flux. Comparing these measurements with ground-based RVs from the NEID instrument, which observes the Sun daily using an automated solar telescope, we find a strong relationship between magnetic activity indicators and RV variation, supporting efforts to examine unsigned magnetic flux as a proxy for stellar activity in slowly rotating stars. Detrending against measured unsigned magnetic flux allows us to improve the NEID RV measurements by ∼20% (∼50 cm s⁻¹ in a quadrature sum), yielding an rms scatter of ∼60 cm s⁻¹ over five months. We also explore correlations between individual and averaged spectral line shapes in the NEID spectra and SDO-derived magnetic activity indicators, motivating future studies of these observables. Finally, applying SolAster to archival planetary transits of Venus and Mercury, we demonstrate the ability to recover small amplitude (<50 cm s⁻¹) RV variations in the SDO data by directly measuring the Rossiter–McLaughlin signals.