Published in
Royal Society of Chemistry, Chemical Science, 25(12), p. 8892-8899, 2021
DOI: 10.1039/d1sc01263k
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Mapping the binding site topology of amyloid protein aggregates using multivalent ligands
Journal article published in 2021 by
Elena Sanna,
Margarida Rodrigues 
,
Steven G. Fagan,
Timothy S. Chisholm ,
Klara Kulenkampff,
David Klenerman,
Maria Grazia Spillantini,
Franklin I. Aigbirhio ,
Christopher A. Hunter
,
Steven G. Fagan,
Timothy S. Chisholm ,
Klara Kulenkampff,
David Klenerman,
Maria Grazia Spillantini,
Franklin I. Aigbirhio ,
Christopher A. Hunter
This paper is made freely available by the publisher.
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Abstract
Multivalent ligands offer a powerful approach to obtain high affinity reagents to bind the aggregates that form in neurodegenerative disease. Selectivity for different proteins was achieved by using different linkers to connect the head groups.