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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(57), p. 1532-1534, 2013

DOI: 10.1128/aac.01436-12

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MIC Values of Voriconazole Are Predictive of Treatment Results in Murine Infections by Aspergillus terreus Species Complex

Journal article published in 2013 by Valentina Salas, F. Javier Pastor, F. Javier Pastor, Deanna A. Sutton, Enrique Calvo, Emilio Mayayo, Annette W. Fothergill, Michael G. Rinaldi, Josep Guarro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We evaluated the efficacy of voriconazole against nine strains of Aspergillus terreus with different MICs (0.12 to 4 μg/ml) by using a murine model. Markers of efficacy included survival, tissue burden, galactomannan antigenemia, and drug serum levels. Voriconazole was especially effective in prolonging survival and reducing the fungal load in infections by strains that showed MICs that were less than or equal to the epidemiological cutoff value (1 μg/ml). In vitro data might be useful for predicting the outcome of A. terreus infections.