AbstractBackground/ObjectivesTo compare survival outcomes for patients with cutaneous invasive head and neck melanoma (HNM) with those of patients with melanoma on other anatomical sites.MethodsRetrospective cohort study using patient data extracted from the Cancer Alliance Queensland's Oncology Analysis System (OASYS) over a 10‐year period from 2009 to 2018. Melanoma‐specific survival was compared between patients with HNM and non‐HNM. Kaplan–Meier survival estimates were calculated at 5 and 10 years. Univariable and multivariable Cox proportional hazards regression analysis determined factors associated with survival.ResultsThe 5‐ and 10‐year survival probabilities were 90.7% and 89.1%, respectively for HNM, compared with 94.7% and 93.0%, respectively, for non‐HNM melanoma. The 5‐ and 10‐year survival probabilities for scalp melanoma were 77.8% and 75.5%, respectively. Patients with HNM died of melanoma at 1.22 times (HR 1.22, 95% CI 1.09–1.37) the rate of those with non‐HNM, controlling for sex, age, socioeconomic status, remoteness, Breslow thickness, the presence of multiple invasion melanoma and ulceration. Patients with scalp melanoma died of melanoma at 1.57 times (HR 1.57, 95% CI 1.26–1.95) the rate of those with non‐scalp HNM.ConclusionsThere is a statistically significant survival difference between patients with HNM and non‐HNM, and between patients with scalp melanoma and non‐scalp HNM, even after adjusting for prognostic factors.