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Nature Research, Scientific Reports, 1(4), 2014

DOI: 10.1038/srep04091

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Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition

Journal article published in 2014 by Erwin Reiling, Ewoud N. Speksnijder, Amanda C. M. Pronk, Sjoerd A. A. van den Berg ORCID, Silvia J. W. Neggers, Ilma Rietbroek, Harry van Steeg, Martijn E. T. Dollé
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.