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Wiley, Research Synthesis Methods, 3(14), p. 468-478, 2023

DOI: 10.1002/jrsm.1626

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RIMeta: An R shiny tool for estimating the reference interval from a meta‐analysis

Journal article published in 2023 by Ziren Jiang ORCID, Wenhao Cao ORCID, Haitao Chu ORCID, Fateh Bazerbachi, Lianne Siegel ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractA reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference interval estimated by combining the data across these studies is typically more generalizable than a reference interval based on a single study. Methods for estimating reference intervals from random effects meta‐analysis and fixed‐effects meta‐analysis have been recently proposed and implemented using R software. We present an R Shiny tool, RIMeta, implementing these methods, which allows users not proficient in R to estimate a reference interval from a meta‐analysis using aggregate data (mean, standard deviation, and sample size) from each study. RIMeta (https://cers.shinyapps.io/RIMeta/) provides users a convenient way to estimate a reference interval from a meta‐analysis and to generate the reference interval plot to visualize the results. The use of this web‐based R Shiny tool does not require the installation of R or any background knowledge of programming. We explain all functions of the R Shiny tool and illustrate how to use it with a real data example.