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Royal Society of Chemistry, Chemical Science, 27(12), p. 9386-9390, 2021

DOI: 10.1039/d1sc01378e

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Scalable synthesis and coupling of quaternary α-arylated amino acids: α-aryl substituents are tolerated in α-helical peptides

Journal article published in 2021 by Daniel J. Leonard ORCID, Francis Zieleniewski ORCID, Isabelle Wellhöfer ORCID, Emily G. Baker ORCID, John W. Ward ORCID, Derek N. Woolfson ORCID, Jonathan Clayden ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Both R and S enantiomers of Fmoc-protected amino acids bearing α-aryl substituents may be made on gram scale. Solid-phase synthesis leads to helical peptides unperturbed by the presence of these additional α-aryl groups.