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- [www.malariajournal.com] | PDF
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Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
,
Arjen Dondorp,
Kamolrat Silamut,
Wirongrong Chierakul,
Sanjeev Krishna ,
Timothy Me Davis ,
Yupin Suputtamongkol,
Brian Angus,
Sasithon Pukrittayakamee,
Ronnatrai Ruangveerayuth,
Josh Hanson,
Nicholas Pj Day,
Nicholas J. White
Abstract
Abstract Background Severe malaria remains a major cause of death and morbidity amongst adults in the Asiatic tropics. Methods A retrospective analysis of the clinical and laboratory data of 988 adult patients, hospitalized with Plasmodium falciparum malaria and prospectively recruited to malaria studies in western Thailand between 1986 and 2002, was performed to assess the factors associated with a fatal outcome. Different severity scores and classifications for defining severe malaria were compared and, using multiple logistic regression, simple models for predicting mortality developed. Results The proportion of patients fulfilling the WHO 2000 definition of severe malaria was 78.1%, and their mortality was 10%. Mortality in patients given parenteral artesunate or artemether (16/317, 5%) was lower than in those given parenteral quinine (59/442, 13%) (P