Published in
American Society for Microbiology, Journal of Virology, 16(95), 2021
DOI: 10.1128/jvi.00588-21
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An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation
Journal article published in 2021 by
Mitchell J. Mumby,
Aaron L. Johnson,
Steven M. Trothen,
Cassandra R. Edgar,
Richard Gibson,
Peter B. Stathopulos 
,
Eric J. Arts,
Jimmy D. Dikeakos
,
Eric J. Arts,
Jimmy D. Dikeakos
This paper is made freely available by the publisher.
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Abstract
A contributing factor to HIV-1 persistence is evasion of the host immune response. HIV-1 uses the Nef accessory protein to evade the antiviral roles of the adaptive and intrinsic innate immune responses.