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Elsevier, Psychoneuroendocrinology, 5(33), p. 569-580

DOI: 10.1016/j.psyneuen.2008.01.018

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Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression

Journal article published in 2008 by Chao Deng ORCID, Mei Han, Thomas Henry Johnston Burne, Kelly A. Newell, Xu-Feng F. Huang ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25 mg/kg/day), olanzapine (1.5 mg/kg/day), haloperidol (0.3 mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p