AbstractBackgroundThe Surveillance for Emerging Threats to Pregnant People and Infants Network (SET‐NET) collects data abstracted from medical records and birth defects registries on pregnant people and their infants to understand outcomes associated with prenatal exposures. We developed an automated process to categorize possible birth defects for prenatal COVID‐19, hepatitis C, and syphilis surveillance. By employing keyword searches, fuzzy matching, natural language processing (NLP), and machine learning (ML), we aimed to decrease the number of cases needing manual clinician review.MethodsSET‐NET captures International Classification of Diseases, 10th Revision, Clinical Modification (ICD‐10‐CM) codes and free text describing birth defects. For unstructured data, we used keyword searches, and then conducted fuzzy matching with a cut‐off match score of ≥90%. Finally, we employed NLP and ML by testing three predictive models to categorize birth defect data.ResultsAs of June 2023, 8326 observations containing data on possible birth defects were submitted to SET‐NET. The majority (n = 6758 [81%]) were matched to an ICD‐10‐CM code and 1568 (19%) were unable to be matched. Through keyword searches and fuzzy matching, we categorized 1387/1568 possible birth defects. Of the remaining 181 unmatched observations, we correctly categorized 144 (80%) using a predictive model.ConclusionsUsing automated approaches allowed for categorization of 99.6% of reported possible birth defects, which helps detect possible patterns requiring further investigation. Without employing these analytic approaches, manual review would have been needed for 1568 observations. These methods can be employed to quickly and accurately sift through data to inform public health responses.