Published in
Royal Society of Chemistry, RSC Advances, 48(11), p. 30315-30328, 2021
DOI: 10.1039/d1ra05925d
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New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
Journal article published in 2021 by
Mohammed M. Alanazi 
,
Hazem Elkady ,
Nawaf A. Alsaif,
Ahmad J. Obaidullah ,
Hamad M. Alkahtani ,
Manal M. Alanazi,
Madhawi A. Alharbi,
Ibrahim H. Eissa ,
Mohammed A. Dahab
,
Hazem Elkady ,
Nawaf A. Alsaif,
Ahmad J. Obaidullah ,
Hamad M. Alkahtani ,
Manal M. Alanazi,
Madhawi A. Alharbi,
Ibrahim H. Eissa ,
Mohammed A. Dahab
This paper is made freely available by the publisher.
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Abstract
A new series of 3-methylquinoxaline-based derivatives having the same pharmacophoric features of VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against MCF-7 and HepG-2 cells.