Objective: To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antim_ullerian hormone, antral follicle count, FSH). Design: Prospective observational study. Setting: Tertiary referral center for reproductive medicine. Patient(s): Women (n =421) undergoing their first cycle of controlled ovarian stimulation for IVF. Intervention(s): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays. Main Outcome Measure(s): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve. Result(s): There was no evidence of any difference in basal FSH, antim_ullerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index. Conclusion(s): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort. (Fertil Steril 2012;97:677-81. 2012 by American Society for Reproductive Medicine.) Key Words: Single nucleotide polymorphism, Ser680Asn, Thr307Ala FSH receptor, antim_ullerian hormone, antral follicle count, follicle-stimulating hormone ; major revision (actually pretty minor!) resub 7/10/11 accepted with minor changes 6/12/11 accepted 21/12/11 pub online 21/1/12 in print: March 2012