AbstractMachine learning models can emulate chemical transport models, reducing computational costs and enabling more experimentation. We developed emulators to predict annual−mean fine particulate matter (PM_2.5) and ozone (O₃) concentrations and their associated chronic health impacts from changes in five major emission sectors (residential, industrial, land transport, agriculture, and power generation) in China. The emulators predicted 99.9% of the variance in PM_2.5 and O₃ concentrations. We used these emulators to estimate how emission reductions can attain air quality targets. In 2015, we estimate that PM_2.5 exposure was 47.4 μg m⁻³ and O₃ exposure was 43.8 ppb, associated with 2,189,700 (95% uncertainty interval, 95UI: 1,948,000–2,427,300) premature deaths per year, primarily from PM_2.5 exposure (98%). PM_2.5 exposure and the associated disease burden were most sensitive to industry and residential emissions. We explore the sensitivity of exposure and health to different combinations of emission reductions. The National Air Quality Target (35 μg m⁻³) for PM_2.5 concentrations can be attained nationally with emission reductions of 72% in industrial, 57% in residential, 36% in land transport, 35% in agricultural, and 33% in power generation emissions. We show that complete removal of emissions from these five sectors does not enable the attainment of the WHO Annual Guideline (5 μg m⁻³) due to remaining air pollution from other sources. Our work provides the first assessment of how air pollution exposure and disease burden in China varies as emissions change across these five sectors and highlights the value of emulators in air quality research.