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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(66), 2022

DOI: 10.1128/aac.00889-22

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Evolution of Fluconazole Resistance Mechanisms and Clonal Types of Candida parapsilosis Isolates from a Tertiary Care Hospital in South Korea

Journal article published in 2022 by Tae Yeul Kim ORCID, Hee Jae Huh, Ga Yeong Lee, Min Ji Choi, Hui-Jin Yu, Sun Young Cho, Yun Sil Chang, Yae-Jean Kim, Jong Hee Shin ORCID, Nam Yong Lee
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We investigated the evolution of fluconazole resistance mechanisms and clonal types of Candida parapsilosis isolates from a tertiary care hospital in South Korea. A total of 45 clinical isolates, including 42 collected between 2017 and 2021 and 3 collected between 2012 and 2013, were subjected to antifungal susceptibility testing, sequencing of fluconazole resistance genes ( ERG11 , CDR1 , TAC1 , and MRR1 ), and microsatellite typing.