Published in

American Association for Cancer Research, Cancer Discovery, 5(12), p. 1195-1198, 2022

DOI: 10.1158/2159-8290.cd-22-0076

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Oncogene Convergence in Extrachromosomal DNA Hubs

Journal article published in 2022 by Natasha E. Weiser ORCID, King L. Hung ORCID, Howard Y. Chang ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local congregations of ecDNAs in the nucleus—highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.