ObjectiveWe aimed to develop and validate a fully automated machine learning (ML) algorithm that predicts bone marrow edema (BME) on a quadrant level in sacroiliac (SI) joint magnetic resonance imaging (MRI).MethodsA computer vision workflow automatically locates the SI joints, segments regions of interest (ilium and sacrum), performs objective quadrant extraction, and predicts presence of BME, suggestive of inflammatory lesions, on a quadrant level in semicoronal slices of T1/T2‐weighted MRI scans. Ground truth was determined by consensus among human readers. The inflammation classifier was trained using a ResNet18 backbone and five‐fold cross‐validated on scans of patients with spondyloarthritis (SpA) (n = 279), postpartum individuals (n = 71), and healthy subjects (n = 114). Independent SpA patient MRI scans (n = 243) served as test data set. Patient‐level predictions were derived from aggregating quadrant‐level predictions, ie, at least one positive quadrant.ResultsThe algorithm automatically detects the SI joints with a precision of 98.4% and segments ilium/sacrum with an intersection over union of 85.6% and 67.9%, respectively. The inflammation classifier performed well in cross‐validation: area under the curve (AUC) 94.5%, balanced accuracy (B‐ACC) 80.5%, and F1 score 64.1%. In the test data set, AUC was 88.2%, B‐ACC 72.1%, and F1 score 50.8%. On a patient level, the model achieved a B‐ACC of 81.6% and 81.4% in the cross‐validation and test data set, respectively.ConclusionWe propose a fully automated ML pipeline that enables objective and standardized evaluation of BME along the SI joints on MRI. This method has the potential to screen large numbers of patients with (suspected) SpA and is a step closer towards artificial intelligence–assisted diagnosis and follow‐up.