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American Society for Microbiology, mBio, 6(13), 2022

DOI: 10.1128/mbio.03052-22

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Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris

Journal article published in 2022 by Aswathy Narayanan, Praveen Kumar, Anshu Chauhan, Mohit Kumar, Kusum Yadav, Atanu Banerjee ORCID, Ravi Datta Sharma ORCID, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti ORCID, Kaustuv Sanyal ORCID, Rajendra Prasad ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Fungal pathogens develop drug resistance through multiple pathways by acquiring gene mutations, increasing the copy number of genes, or altering gene expression. In this study, we attempt to understand the mechanisms of drug resistance in the recently emerged superbug, C. auris .