American Society for Microbiology, Journal of Virology, 7(96), 2022
DOI: 10.1128/jvi.02161-21
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This study presents that ICVAX, a PD1-based DNA vaccine against HIV-1, could induce broad and polyfunctional T cell responses against different HIV-1 subtypes. ICVAX encodes a recombinant antigen consisting of the human soluble PD1 domain fused with two mosaic Gag-p41 antigens.