Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
Journal article published in 2021 by
Ruben Dyrhovden 
,
Martin Rippin ,
Kjell Kåre Øvrebø,
Randi M. Nygaard,
Elling Ulvestad,
Øyvind Kommedal
,
Martin Rippin ,
Kjell Kåre Øvrebø,
Randi M. Nygaard,
Elling Ulvestad,
Øyvind Kommedal
This paper is made freely available by the publisher.
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Abstract
There has been a gradual increase in 16S deep sequencing studies on infectious disease materials. Management of bacterial DNA contamination is a major challenge in such diagnostics, particularly in low biomass samples.