AbstractIn recent years, perovskite solar cells (PSCs) have attracted significant attention due to their excellent photoelectric properties. However, several key performance parameters of these devices still fall short of their theoretical limits. Among these parameters, the regulation of open‐circuit voltage (V_OC) has been a focal point of intensive research efforts, playing a pivotal role in advancing the efficiency of PSCs. This review first provides an overview of the generation and loss mechanism of V_OC. It then discusses the significance of interface engineering in V_OC regulation. Recent developments in high‐efficiency PSCs realized via interface engineering have been summarized and categorized into three key areas: surface modification, interface structure optimization, and surface dimensional engineering. Finally, a comprehensive summary of past research in this domain and offered insights into the future prospects of enhancing V_OC in PSCs is provided.