Published in

The Royal Society, Interface, 177(18), 2021

DOI: 10.1098/rsif.2020.0881

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Arterial pulse wave propagation across stenoses and aneurysms: assessment of one-dimensional simulations against three-dimensional simulations andin vitromeasurements

Journal article published in 2021 by Weiwei Jin ORCID, Jordi Alastruey ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Data provided by SHERPA/RoMEO

Abstract

One-dimensional (1-D) arterial blood flow modelling was tested in a series of idealized vascular geometries representing the abdominal aorta, common carotid and iliac arteries with different sizes of stenoses and/or aneurysms. Three-dimensional (3-D) modelling andin vitromeasurements were used as ground truth to assess the accuracy of 1-D model pressure and flow waves. The 1-D and 3-D formulations shared identical boundary conditions and had equivalent vascular geometries and material properties. The parameters of an experimental set-up of the abdominal aorta for different aneurysm sizes were matched in corresponding 1-D models. Results show the ability of 1-D modelling to capture the main features of pressure and flow waves, pressure drop across the stenoses and energy dissipation across aneurysms observed in the 3-D and experimental models. Under physiological Reynolds numbers (Re), root mean square errors were smaller than 5.4% for pressure and 7.3% for the flow, for stenosis and aneurysm sizes of up to 85% and 400%, respectively. Relative errors increased with the increasing stenosis and aneurysm size, aneurysm length andRe, and decreasing stenosis length. All data generated in this study are freely available and provide a valuable resource for future research.