Abstract There are hundreds of millions of kilometers of paved roads and many people live in proximity. Pollution from road transportation is a well-documented problem potentially leading to chronic health impacts. However, research on the raw material production, construction, operation, maintenance, and end-of-life phases of paved roads, and corresponding supply chains, is generally limited to energy consumption and greenhouse gas emissions. No previous research efforts on the life-cycle stages of pavements and road operation connect pollutant emission inventories to intake of inhaled pollutants and resulting damages to exposed populations. We have developed a first-of-its-kind model quantifying human exposure to fine particulate matter (PM_2.5) due to emissions from routine pavement resurfacing and vehicle operation. We utilize the Intervention Model Pollution Source-Receptor Matrix to calculate marginal changes in ground-level PM_2.5 concentrations and resulting exposure intake from a spatially resolved primary and secondary PM_2.5 emission precursors inventory. Under a scenario of annual road-resurfacing practices within the San Francisco Bay Area in California (population: 7.5 million), resurfacing activities, material production and delivery (i.e. cement, concrete, aggregate, asphalt, bitumen), and fuel (i.e. gasoline, diesel) supply chains contribute almost 65% to the annual PM_2.5 intake from all the sources included in the study domain (the remaining 35% being due to on-road tailpipe emissions). Exposure damages range from $170 to $190 million (2019 USD). Complete electrification of on-road mobile sources would reduce annual intake by 64%, but a sizable portion would remain from material supply chains, construction activities, and brake and tire wear. Future mitigation policies should be enacted equitably. Results show that people of color experience higher-than-average PM_2.5 exposure disparities from the emission sources included in the study, particularly from material production.