Fritts et al. (J. Fluid Mech., vol. xx, 2022, xx) describe a direct numerical simulation of interacting Kelvin–Helmholtz instability (KHI) billows arising due to initial billow cores that exhibit variable phases along their axes. Such KHI exhibit strong ‘tube and knot’ dynamics identified in early laboratory studies by Thorpe (Geophys. Astrophys. Fluid Dyn., vol. 34, 1985, pp. 175–199). Thorpe (Q.J.R. Meteorol. Soc., vol. 128, 2002, pp. 1529–1542) noted that these dynamics may be prevalent in the atmosphere, and they were recently identified in atmospheric observations at high altitudes. Tube and knot dynamics were found by Fritts et al. (J. Fluid. Mech., 2022) to drive stronger and faster turbulence transitions than secondary instabilities of individual KH billows. Results presented here reveal that KHI tube and knot dynamics also yield energy dissipation rates $∼$ 2–4 times larger as turbulence arises and that remain $∼$ 2–3 times larger to later stages of the flow evolution, compared with those of secondary convective instabilities (CI) and secondary KHI accompanying KH billows without tube and knot influences. Elevated energy dissipation rates occur due to turbulence transitions by tube and knot dynamics arising on much larger scales than secondary CI and KHI where initial KH billows are misaligned. Tube and knot dynamics also excite large-scale Kelvin ‘twist waves’ that cause vortex tube and billow core fragmentation, more energetic cascades of similar interactions to smaller scales and account for the strongest energy dissipation events accompanying such KH billow evolutions.