AbstractLong‐term efforts have sought to extend global model resolution to smaller scales enabling more accurate descriptions of gravity wave (GW) sources and responses, given their major roles in coupling and variability throughout the atmosphere. Such studies reveal significant improvements accompanying increasing resolution, but no guidance on what is sufficient to approximate reality. We take the opposite approach, using a finite‐volume model solving the Navier‐Stokes equations exactly. The reference simulation addresses mountain wave (MW) generation and responses over the Southern Andes described using isotropic 500 m, central resolution by Fritts et al. (2021), https://doi.org/10.1175/JAS-D-20-0207.1 and Lund et al. (2020), https://doi.org/10.1175/JAS-D-19-0356.1. Reductions of horizontal resolution to 1 and 2 km result in (a) systematic increases in initial MW breaking altitudes, (b) weaker, larger‐scale generation of secondary GWs and acoustic waves accompanying these dynamics, and (c) significantly weaker and less extended responses in the mesosphere in latitude and longitude. Horizontal resolution of 4 km largely suppresses instabilities, but allows weak, sustained mean‐flow interactions. Responses for 8 km resolution are very weak and fail to capture any aspects of the high‐resolution responses. The chosen mean winds allow efficient MW penetration into the mesosphere and lower thermosphere, hence only exhibit strong pseudo‐momentum deposition and mean wind decelerations at higher altitudes. A companion paper by Fritts et al. (2022), https://doi.org/10.1029/2021JD036035 explores the impacts of decreasing resolution on responses in the thermosphere.