The results of the annual excursion of the Working Group for Vegetation Science of the Italian Botanical Society, held in the Egadi Islands, Mount San Giuliano and Mount Cofano (W Sicily) on April 23–27 2022, are presented. This paper includes: (1) general information on the visited sites; (2) geology and geomorphology; (3) climatology and bioclimatology with tables of climatic data; (4) description of the following five geobotanical itineraries – accompanied by 29 original vegetation relevés and 11 synthetic relevés, proceeding from different bibliographic references: (a) Mount San Giuliano; (b) Marettimo Island: coastal and sub-coastal stretch of the southern part, between Punta Bassana and Contrada Chiappera; (c) Marettimo Island: Case Romane, Mount Pizzo Falcone and the north-western coastal stretch; (d) Island of Levanzo; (e) Mount Cofano – with catenal pictograms of the vegetation, surveys and description of the plant communities and related syntaxonomic scheme; (5) list of the surveyed plant taxa, collected specimens and herbaria in which they are deposited. A new syntaxon is also described (Catapodio pauciflori-Moraeetum sisyrinchii ass. nova), referring to an ephemeral dry grassland located along the north-western coastal stretch of Marettimo. The new association is framed in the Plantagini-Catapodion balearici, alliance of the Stipo-Bupleuretalia semicompositi order of the class Stipo-Trachynietea distachyae (order Stipo-Bupleuretalia semicompositi, alliance Plantagini-Catapodion balearici). An original synoptic table, regarding 17 different plant communities with high frequency of Moraea sisyrinchium, provides a comparative framework of the new association with allied vegetation units so far described throughout the Mediterranean region. Syntaxonomical and nomenclatural remarks regarding the Mediterranean vegetation occurring in this territory are also given throughout the text. Some floristic updates for the study sites are also reported, including the discovery for the first time in Sicily of Lysimachia loeflingii.