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Royal Society of Chemistry, Chemical Science, 3(14), p. 506-513, 2023

DOI: 10.1039/d2sc05897a

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In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chiral metallohelix ΛA inhibited amyloid-β aggregation with enantioselectivity in vivo. Beyond the intrinsic bioactivity, alkyne-bearing ΛA was employed as a building block for convenient visualization and versatile modification via click reaction.