Published in

Wiley Open Access, Journal of Diabetes Investigation, 10(12), p. 1827-1834, 2021

DOI: 10.1111/jdi.13542

Links

Tools

Export citation

Search in Google Scholar

Falls and fractures associated with type 2 diabetic polyneuropathy: A cross‐sectional nationwide questionnaire study

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Green circle
Published version: archiving allowed
Data provided by SHERPA/RoMEO

Abstract

AbstractAims/IntroductionTo examine the prevalence of falls and fractures, and the association with symptoms of diabetic polyneuropathy (DPN) in patients with recently diagnosed type 2 diabetes.Materials and MethodsA detailed questionnaire on neuropathy symptoms and falls was sent to 6,726 patients enrolled in the Danish Center for Strategic Research in Type 2 Diabetes cohort (median age 65 years, diabetes duration 4.6 years). Complete data on fractures and patient characteristics were ascertained from population‐based health registries. We defined possible DPN as a score ≥4 on the Michigan Neuropathy Screening Instruments questionnaire. Using Poisson regression analyses, we estimated the adjusted prevalence ratio (aPR) of falls and fractures, comparing patients with and without DPN.ResultsIn total, 5,359 patients (80%) answered the questions on the Michigan Neuropathy Screening Instruments questionnaire and falls. Within the year preceding the questionnaire response, 17% (n = 933) reported at least one fall and 1.4% (n = 76) suffered from a fracture. The prevalence ratio of falls was substantially increased in patients with possible DPN compared with those without (aPR 2.33, 95% confidence interval [CI] 2.06–2.63). The prevalence ratio increased with the number of falls from aPR 1.51 (95% CI 1.22–1.89) for one fall to aPR 5.89 (95% CI 3.84–9.05) for four or more falls within the preceding year. Possible DPN was associated with a slightly although non‐significantly increased risk of fractures (aPR 1.32, 95% CI 0.75–2.33).ConclusionsPatients with recently diagnosed type 2 diabetes and symptoms of DPN had a highly increased risk of falling. These results emphasize the need for preventive interventions to reduce fall risk among patients with type 2 diabetes and possible DPN.